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The effect of increased testosterone concentration on pregnancy is difficult to clearly establish, as both no effect on the course of pregnancy (304) and an increased risk of preeclampsia (305) have been demonstrated

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A number of medications, including Interlukin-17 (IL-17) solanezumab, bapineuzumab, avagacestat, and tarenflurbil, have entered clinical trials, although they have not yet shown clinically significant efficacy